To understand how the brain processes sensory information to guide behavior, we must know
how stimulus representations are transformed throughout the visual cortex. Here we report …

Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique,
care must be taken to ensure that the tool itself does not unduly affect the system under study. …

Using a murine respiratory challenge model we have previously demonstrated a role for
Th1 cells in natural immunity against Bordetella pertussis, but could not rule out a role for …

10.7554/eLife.31126.001 As more people live longer, age-related neurodegenerative
diseases are an increasingly important societal health issue. Treatments targeting specific …

Using a murine respiratory infection model, we have demonstrated previously that infection
with Bordetella pertussis or immunization with a whole-cell pertussis vaccine induced antigen…

Quickly and flexibly exploring high-dimensional datasets, such as scRNAseq data, is
underserved but critical for hypothesis generation, dataset annotation, publication, sharing, and …

Identification of structural connections between neurons is a prerequisite to understanding
brain function. Here we developed a pipeline to systematically map brain-wide monosynaptic …

Despite recent advances, there is still a major need to better understand the interactions
between brain function and chronic gut inflammation and its clinical implications. Alterations in …

We have used a murine respiratory challenge model to examine the local T cell responses
in the lung during infection with Bordetella pertussis. T cells from lung parenchyma and …

To understand how the brain processes sensory information to guide behavior, we must know
how stimulus representations are transformed throughout the visual cortex. Here we report …