User profiles for Fiona James

Fiona James

Associate Professor, Ontario Veterinary College, University of Guelph
Verified email at uoguelph.ca
Cited by 466

[HTML][HTML] Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

…, R James, S Sitnikov, I Lundgaard, F James… - Nature …, 2015 - nature.com
Myelin regeneration can occur spontaneously in demyelinating diseases such as multiple
sclerosis (MS). However, the underlying mechanisms and causes of its frequent failure remain …

[PDF][PDF] CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

…, S Sonda, J Kaur, LM Wakim, GP Westall, F James… - Immunity, 2021 - cell.com
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),
it is important to examine unmanipulated severe acute respiratory syndrome …

Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: the PALACE randomized clinical trial

AM Copaescu, S Vogrin, F James… - JAMA internal …, 2023 - jamanetwork.com
Importance Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The
standard of care to remove the penicillin allergy label in adults is specialized testing …

[HTML][HTML] SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

…, L Hensen, DF Boyd, F James… - Nature …, 2022 - nature.com
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …

Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1

F Wielaender, R Sarviaho, F James… - Proceedings of the …, 2017 - National Acad Sciences
The clinical and electroencephalographic features of a canine generalized myoclonic epilepsy
with photosensitivity and onset in young Rhodesian Ridgeback dogs (6 wk to 18 mo) are …

[HTML][HTML] Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer

FR James, M Jiminez-Linan, J Alsop, M Mack, H Song… - BMC cancer, 2017 - Springer
Background There is evidence that some ovarian tumours evoke an immune response, which
can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as …

[PDF][PDF] Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells

…, S Nicholson, F Krammer, G Gibney, F James… - Cell Reports …, 2023 - cell.com
Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond
poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 …

[HTML][HTML] Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: a validation and …

…, O Smibert, G Drewett, F James… - The Lancet Regional …, 2021 - thelancet.com
Background In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively
costly and time-consuming. To date, few studies have assessed the performance and …

[HTML][HTML] Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations

…, JH McMahon, PG Thomas, PS Pannaraj, F James… - JCI insight, 2023 - ncbi.nlm.nih.gov
Pregnancy poses a greater risk for severe COVID-19; however, underlying immunological
changes associated with SARS-CoV-2 during pregnancy are poorly understood. We defined …

Decision-making in intensive care medicine–A review

FR James, N Power, S Laha - Journal of the Intensive Care …, 2018 - journals.sagepub.com
Decision-making by intensivists around accepting patients to intensive care units is a complex
area, with often high-stakes, difficult, emotive decisions being made with limited patient …