Functional genomics approaches can overcome limitations—such as the lack of identification
of robust targets and poor clinical efficacy—that hamper cancer drug development. Here …

Genome-scale CRISPR-Cas9 viability screens performed in cancer cell lines provide a
systematic approach to identify cancer dependencies and new therapeutic targets. As multiple …

Many gene fusions are reported in tumours and for most their role remains unknown. As
fusions are used for diagnostic and prognostic purposes, and are targets for treatment, it is …

CRISPR genetic screens in cancer cell models are a powerful tool to elucidate oncogenic
mechanisms and to identify promising therapeutic targets. The Project Score database ( https://…

Background Genome editing by CRISPR-Cas9 technology allows large-scale screening of
gene essentiality in cancer. A confounding factor when interpreting CRISPR-Cas9 screens is …

Low success rates during drug development are due, in part, to the difficulty of defining drug
mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated …

New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We
conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived …

CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient
reagents, although their large size is a barrier for many applications. We design an …

Background CRISPR-Cas9 genome editing is widely used to study gene function, from
basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of …

Genetic screens in cancer cell lines inform gene function and drug discovery. More
comprehensive screen datasets with multi-omics data are needed to enhance opportunities to …