Zinc-fingers (ZnFs) are extremely abundant in higher eukaryotes. Once considered to
function exclusively as sequence-specific DNA-binding motifs, ZnFs are now known to have …

Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …

Lin28 inhibits the biogenesis of let-7 miRNAs through a direct interaction with the terminal
loop of pre-let-7. This interaction requires the zinc-knuckle domains of Lin28. We show that the …

The gene-for-gene mechanism of plant disease resistance involves direct or indirect
recognition of pathogen avirulence (Avr) proteins by plant resistance (R) proteins. Flax rust (…

The recognition of single-stranded RNA (ssRNA) is an important aspect of gene regulation,
and a number of different classes of protein domains that recognize ssRNA in a sequence-…

The alternative splicing of mRNA is a critical process in higher eukaryotes that generates
substantial proteomic diversity. Many of the proteins that are essential to this process contain …

Mutations in the RNA-binding protein Fused in Sarcoma (FUS) cause early-onset amyotrophic
lateral sclerosis (ALS). However, a detailed understanding of central RNA targets of FUS …

GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that physically interact
to play essential roles in erythroid and megakaryocytic development. Several naturally …

TIA-1 is an RNA-binding protein that sequesters target RNA into stress granules under
conditions of cellular stress. Promotion of stress granule formation by TIA-1 depends upon self-…

Highlights • Common and unique features influence RNA interaction and self-association by
TDP-43 and FUS. • TDP-43 binds RNA sequence specifically whereas FUS binds both …