[HTML][HTML] Comparison of a machine and deep learning model for automated tumor annotation on digitized whole slide prostate cancer histology

…, SA Bobholz, AK Lowman, A Winiarz, F Kyereme… - Plos one, 2023 - journals.plos.org
One in eight men will be affected by prostate cancer (PCa) in their lives. While the current
clinical standard prognostic marker for PCa is the Gleason score, it is subject to inter-reviewer …

[HTML][HTML] Whole slide imaging (WSI) scanner differences influence optical and computed properties of digitized prostate cancer histology

…, MA Stebbins, A Winiarz, B Nath, F Kyereme… - Journal of Pathology …, 2023 - Elsevier
Purpose Digital pathology is becoming an increasingly popular area of advancement in both
research and clinically. Pathologists are now able to manage and interpret slides digitally, …

[HTML][HTML] Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response

…, A Winiarz, SR Duenweg, F Kyereme… - Journal of Neuro …, 2024 - Springer
Background Autopsy-based radio-pathomic maps of glioma pathology have shown substantial
promise inidentifying areas of non-enhancing tumor presence, which may be able to …

[HTML][HTML] Quantitative Histomorphometric Features of Prostate Cancer Predict Patients Who Biochemically Recur Following Prostatectomy

…, M Brehler, AK Lowman, SA Bobholz, F Kyereme… - Laboratory …, 2023 - Elsevier
Prostate cancer is the most commonly diagnosed cancer in men, accounting for 27% of the
new male cancer diagnoses in 2022. If organ-confined, removal of the prostate through …

[HTML][HTML] Diffusion restriction comparison between gleason 4 fused glands and cribriform glands within patient using whole-mount prostate pathology as ground truth

…, SA Bobholz, AK Lowman, M Brehler, F Kyereme… - Tomography, 2022 - mdpi.com
The presence and extent of cribriform patterned Gleason 4 (G4) glands are associated with
poor prognosis following radical prostatectomy. This study used whole-mount prostate …

Non-invasive tumor probability maps developed using autopsy tissue identify novel areas of tumor beyond the imaging-defined margin

…, AK Lowman, JM Connelly, SR Duenweg, F Kyereme… - medRxiv, 2022 - medrxiv.org
Background This study identified a clinically significant subset of glioma patients with tumor
outside of contrast-enhancement present at autopsy, and subsequently developed a method …

STEM-10. SOX2 POSITIVE, PRESUMED TUMOR INVASION MEASURED WELL BEYOND CONTRAST ENHANCEMENT AND FLAIR HYPERINTENSITY IN BOTH …

…, A Lowman, M Flatley, B Nath, F Kyereme… - Neuro …, 2023 - academic.oup.com
Glioblastomas (GBM) are defined by cell type heterogeneity that underlies treatment resistance
and brain invasion. Recent studies have identified reactivation of neurodevelopmental …

Radio-pathomic maps of cell density identify glioma invasion beyond traditional MR imaging defined margins

SA Bobholz, AK Lowman, M Brehler, F Kyereme… - bioRxiv, 2021 - biorxiv.org
Current MRI signatures of brain cancer often fail to identify regions of hypercellularity beyond
the contrast enhancing region. Therefore, this study used autopsy tissue samples aligned …

An automated approach for annotation Gleason patterns in whole-mount prostate cancer histology using deep learning

…, SA Bobholz, SR Duenweg, F Kyereme… - SPIE. San Diego …, 2022 - spiedigitallibrary.org
Prostate cancer (PCa) accounts for 26% of new cancer diagnoses in men1, making it the
most diagnosed common non-cutaneous cancer in men. Early and accurate detection of …

[HTML][HTML] Noninvasive Autopsy-Validated Tumor Probability Maps Identify Glioma Invasion Beyond Contrast Enhancement

…, SR Duenweg, A Winiarz, B Nath, F Kyereme… - …, 2022 - journals.lww.com
METHODS: A total of 159 tissue samples from 65 subjects were aligned to MRI acquired
nearest to death for this retrospective study. Demographic and survival characteristics for …