Reverse transcription-derived sequences account for at least half of the human genome.
Although these retroelements are formidable motors of evolution, they can occasionally cause …

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic
or diseased brain-dead donors and thus cannot accurately describe the molecular …

Vertebrate genomes are partitioned into contact domains defined by enhanced internal
contact frequency and formed by two principal mechanisms: compartmentalization of …

TRIMCyps are primate antiretroviral proteins that potently inhibit HIV replication. Here we
describe how rhesus macaque TRIMCyp (RhTC) has evolved to target and restrict HIV-2. We …

Context Reduced β-cell mass, impaired islet function, and dedifferentiation are considered
causal to development of hyperglycemia and type 2 diabetes. In human cohort studies, …

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old
World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of …

Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However,
genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain …

Expanded CAG/CTG repeats underlie 13 neurological disorders, including myotonic
dystrophy type 1 (DM1) and Huntington’s disease (HD). Upon expansion, disease loci acquire …

Aims/hypothesis Repeated exposures to insulin-induced hypoglycaemia in people with
diabetes progressively impairs the counterregulatory response (CRR) that restores …

Viral tropism, replication, and pathogenesis are determined by multiple interactions
between the pathogen and the host. In the case of retroviruses, and in particular, the human …