Using siRNAs to genetically manipulate immune cells is important to both basic immunological
studies and therapeutic applications. However, siRNA delivery is challenging because …

Understanding the mechanisms of cancer initiation will help to prevent and manage the
disease. At present, the role of the breast microenvironment in transformation remains unknown. …

Background and Aims Inflammatory bowel diseases are highly debilitating conditions that
require constant monitoring and life-long medication. Current treatments are focused on …

L'incidence, le coût et l'issue fatale dans un nombre encore trop élevé de cas font du cancer
un problème majeur en santé publique. Malgré les progrès réalisés dans le développement …

Bone morphogenetic protein 2 (BMP2) and BMP4 are key regulators of the fate and
differentiation of human mammary epithelial stem cells (SCs), as well as of their niches, and are …

Stem cells (SCs) have been extensively studied in the context of regenerative medicine.
Human hematopoietic stem cell (HSC)-based therapies have been applied to treat leukemic …

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with one of
the highest mortality rates among solid cancers. It develops almost exclusively in the …

Nonviral systems, such as lipid nanoparticles, have emerged as reliable methods to enable
nucleic acid intracellular delivery. The use of cationic lipids in various formulations of lipid …

Les îlots de Langerhans isolés de donneurs en état de mort encéphalique constituent
actuellement la seule source de cellules pour la transplantation de patients atteints de diabète de …

An accurate estimate of patient survival at diagnosis is critical to plan efficient therapeutic
options. A simple and multiapplication tool is needed to move forward the precision medicine …