Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …

Cell signaling mechanisms often transmit information via posttranslational protein modifications,
most importantly reversible protein phosphorylation. Here we develop and apply a …

Eukaryotic cells replicate by a complex series of evolutionarily conserved events that are
tightly regulated at defined stages of the cell division cycle. Progression through this cycle …

Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis.
Here, we obtained exome, transcriptome and copy-number alteration data from …

Identifying and understanding changes in cancer genomes is essential for the development
of targeted therapeutics 1 . Here we analyse systematically more than 70 pairs of primary …

N-linked glycosylation is a biologically important protein modification, but only a small fraction
of modification sites have been mapped. We developed a "filter aided sample preparation" …

We analyzed transcriptomes (n = 211), whole exomes (n = 99) and targeted exomes (n =
103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …

Protein kinases are pivotal regulators of cell signaling that modulate each other's functions
and activities through site-specific phosphorylation events. These key regulatory …

Tumor-derived cell lines have served as vital models to advance our understanding of
oncogene function and therapeutic responses. Although substantial effort has been made to …

PHOSIDA http://www.phosida.com , a phosphorylation site database, integrates thousands of
high-confidence in vivo phosphosites identified by mass spectrometry-based proteomics in …