User profiles for Florian Meier

Florian Meier

Jena University Hospital and Max Planck Institute of Biochemistry
Verified email at biochem.mpg.de
Cited by 4139

diaPASEF: parallel accumulation–serial fragmentation combined with data-independent acquisition

F Meier, AD Brunner, M Frank, A Ha, I Bludau… - Nature …, 2020 - nature.com
Data-independent acquisition modes isolate and concurrently fragment populations of different
precursors by cycling through segments of a predefined precursor m/z range. Although …

[HTML][HTML] Online parallel accumulation–serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer

F Meier, AD Brunner, S Koch, H Koch, M Lubeck… - Molecular & Cellular …, 2018 - ASBMB
In bottom-up proteomics, peptides are separated by liquid chromatography with elution
peak widths in the range of seconds, whereas mass spectra are acquired in about 100 …

Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation

…, DS Fischer, O Raether, MA Park, F Meier… - Molecular systems …, 2022 - embopress.org
Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging
and deep sequencing. However, proteins are the main drivers of cellular function and in‐…

BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes

F Meier, PE Geyer, S Virreira Winter, J Cox, M Mann - Nature methods, 2018 - nature.com
Great advances have been made in sensitivity and acquisition speed on the Orbitrap mass
analyzer, enabling increasingly deep proteome coverage. However, these advances have …

Parallel accumulation–serial fragmentation (PASEF): multiplying sequencing speed and sensitivity by synchronized scans in a trapped ion mobility device

F Meier, S Beck, N Grassl, M Lubeck… - Journal of proteome …, 2015 - ACS Publications
In liquid chromatography-mass spectrometry (LC-MS)-based proteomics, many precursors
elute from the column simultaneously. In data-dependent analyses, these precursors are …

Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database

FMP Meier, KW Frommer, R Dinser… - Annals of the …, 2012 - ard.bmj.com
Objectives Systemic sclerosis (SSc) is a rare disease requiring multicentre collaboration to
reveal comprehensive details of disease-related causes for morbidity and mortality. Methods …

Quantum computing with spin cluster qubits

F Meier, J Levy, D Loss - Physical review letters, 2003 - APS
We study the low energy states of finite spin chains with isotropic (Heisenberg) and anisotropic
(XY and Ising-like) antiferromagnetic exchange interaction with uniform and nonuniform …

[HTML][HTML] A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics

…, PV Treit, S Doll, I Paron, JB Müller, F Meier… - Molecular & Cellular …, 2018 - ASBMB
To further integrate mass spectrometry (MS)-based proteomics into biomedical research and
especially into clinical settings, high throughput and robustness are essential requirements. …

Magnetization transport and quantized spin conductance

F Meier, D Loss - Physical review letters, 2003 - APS
We analyze transport of magnetization in insulating systems described by a spin Hamiltonian.
The magnetization current through a quasi-one-dimensional magnetic wire of finite length …

[HTML][HTML] Region and cell-type resolved quantitative proteomic map of the human heart

…, DN Itzhak, C Braun, SA Doppler, F Meier… - Nature …, 2017 - nature.com
The heart is a central human organ and its diseases are the leading cause of death worldwide,
but an in-depth knowledge of the identity and quantity of its constituent proteins is still …