The Online Chemical Modeling Environment is a web-based platform that aims to automate
and simplify the typical steps required for QSAR modeling. The platform consists of two …

Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver…

We have applied the k-nearest neighbor (kNN) modeling technique to the prediction of melting
points. A data set of 4119 diverse organic molecules (data set 1) and an additional set of …

This paper attempts to elucidate differences in QSPR models of aqueous solubility (Log S),
melting point (T m ), and octanol−water partition coefficient (Log P), three properties of …

Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …

Due to evolutionary conservation of biology, experimental knowledge captured from genetic
studies in eukaryotic model organisms provides insight into human cellular pathways and …

Fibrosis is characterized by the excessive production of collagen and other extracellular matrix
(ECM) components and represents a leading cause of morbidity and mortality worldwide. …

Since the advent of high-throughput screening (HTS), there has been an urgent need for
methods that facilitate the interrogation of large-scale chemical biology data to build a mode of …

Human organoids allow the study of proliferation, lineage specification, and 3D tissue
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem cell (…