A central goal of genetics is to define the relationships between genotypes and phenotypes.
High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single-…

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved
in multiple aspects of messenger RNA metabolism, including the repression of alternative …

B-DNA becomes unstable under superhelical stress and is able to adopt a wide range of
alternative conformations including strand-separated DNA and Z-DNA. Localized sequence-…

Here we introduce a mostly natural sequencing-by-synthesis (mnSBS) method for single-cell
RNA sequencing (scRNA-seq), adapted to the Ultima genomics platform, and …

A code predicting the RNA sequence that will be bound by a certain protein based on its
amino acid sequence or its structure would provide a useful tool for the design of RNA binders …

Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet
sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their …

Proteins of the RsmA/CsrA family are global translational regulators in many bacterial
species. We have determined the solution structure of a complex formed between the RsmE …

Although the abundant sterile alpha motif (SAM) domain was originally classified as a
protein-protein interaction domain, it has recently been shown that certain SAM domains have the …

Single-molecule measurements of DNA twist and extension have been used to reveal
physical properties of the double helix and to characterize structural dynamics and …

Over the past two decades, measurements on individual stretched and twisted DNA molecules
have helped define the basic elastic properties of the double helix and enabled real-time …