[PDF][PDF] Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
…, G Lithwick-Yanai, N Iremadze, F Oberstrass… - Cell, 2022 - cell.com
A central goal of genetics is to define the relationships between genotypes and phenotypes.
High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single-…
High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single-…
Structure of PTB bound to RNA: specific binding and implications for splicing regulation
FC Oberstrass, SD Auweter, M Erat, Y Hargous… - Science, 2005 - science.org
The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved
in multiple aspects of messenger RNA metabolism, including the repression of alternative …
in multiple aspects of messenger RNA metabolism, including the repression of alternative …
Torque measurements reveal sequence-specific cooperative transitions in supercoiled DNA
FC Oberstrass, LE Fernandes… - Proceedings of the …, 2012 - National Acad Sciences
B-DNA becomes unstable under superhelical stress and is able to adopt a wide range of
alternative conformations including strand-separated DNA and Z-DNA. Localized sequence-…
alternative conformations including strand-separated DNA and Z-DNA. Localized sequence-…
[HTML][HTML] Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing
…, G Lithwick-Yanai, X Adiconis, F Oberstrass… - Nature …, 2023 - nature.com
Here we introduce a mostly natural sequencing-by-synthesis (mnSBS) method for single-cell
RNA sequencing (scRNA-seq), adapted to the Ultima genomics platform, and …
RNA sequencing (scRNA-seq), adapted to the Ultima genomics platform, and …
Sequence-specific binding of single-stranded RNA: is there a code for recognition?
SD Auweter, FC Oberstrass, FHT Allain - Nucleic acids research, 2006 - academic.oup.com
A code predicting the RNA sequence that will be bound by a certain protein based on its
amino acid sequence or its structure would provide a useful tool for the design of RNA binders …
amino acid sequence or its structure would provide a useful tool for the design of RNA binders …
[HTML][HTML] The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove
R Stefl, FC Oberstrass, JL Hood, M Jourdan… - Cell, 2010 - cell.com
Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet
sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their …
sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their …
Molecular basis of messenger RNA recognition by the specific bacterial repressing clamp RsmA/CsrA
…, K Lapouge, O Duss, FC Oberstrass… - Nature structural & …, 2007 - nature.com
Proteins of the RsmA/CsrA family are global translational regulators in many bacterial
species. We have determined the solution structure of a complex formed between the RsmE …
species. We have determined the solution structure of a complex formed between the RsmE …
Shape-specific recognition in the structure of the Vts1p SAM domain with RNA
FC Oberstrass, A Lee, R Stefl, M Janis… - Nature structural & …, 2006 - nature.com
Although the abundant sterile alpha motif (SAM) domain was originally classified as a
protein-protein interaction domain, it has recently been shown that certain SAM domains have the …
protein-protein interaction domain, it has recently been shown that certain SAM domains have the …
Gold rotor bead tracking for high-speed measurements of DNA twist, torque and extension
Single-molecule measurements of DNA twist and extension have been used to reveal
physical properties of the double helix and to characterize structural dynamics and …
physical properties of the double helix and to characterize structural dynamics and …
Recent developments in single-molecule DNA mechanics
Z Bryant, FC Oberstrass, A Basu - Current opinion in structural biology, 2012 - Elsevier
Over the past two decades, measurements on individual stretched and twisted DNA molecules
have helped define the basic elastic properties of the double helix and enabled real-time …
have helped define the basic elastic properties of the double helix and enabled real-time …