Over the past 100 years, changes in the food supply in Western nations have resulted in
alterations in dietary fatty acid consumption, leading to a dramatic increase in the ratio of omega-…

Over the past few decades, the fundamental concept that the in vivo modulation of levels of
arachidonic acid (AA) is intimately linked to cellular function and human disease has been …

Gamma-linolenic acid (GLA, 18:3n-6) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated
fatty acid (PUFA) found in human milk and several botanical seed oils and is typically …

Cancer metastasis accounts for the major cause of cancer-related deaths. How
disseminated cancer cells cope with hostile microenvironments in secondary site for full-blown …

To understand the in vivo metabolism of dietary γ-linolenic acid (GLA), we supplemented the
diets of 29 volunteers with GLA in doses of 1.5–6.0 g/d. Twenty-four subjects ate controlled …

There is an urgent need to identify the cellular and molecular mechanisms responsible for
severe COVID-19 that results in death. We initially performed both untargeted and targeted …

Over the past 50 years, increases in dietary n-6 PUFA, such as linoleic acid, have been
hypothesised to cause or exacerbate chronic inflammatory diseases. The present study …

Previous studies reveal that supplementation of human diets with γ-linolenic acid (GLA)
reduces the generation of lipid mediators of inflammation and attenuates clinical symptoms of …

The “modern western” diet (MWD) has increased the onset and progression of chronic human
diseases as qualitatively and quantitatively maladaptive dietary components give rise to …

Background Arachidonic acid (AA) is a long-chain omega-6 polyunsaturated fatty acid (PUFA)
synthesized from the precursor dihomo-gamma-linolenic acid (DGLA) that plays a vital …