Background & Aims: Progressive familial intrahepatic cholestasis (PFIC), an inherited liver
disease of childhood, is characterized by cholestasis and either normal or increased serum γ-…

The incidence of the metabolic syndrome has taken epidemic proportions in the past decades,
contributing to an increased risk of cardiovascular disease and diabetes. The metabolic …

The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette
family of drug transporters and confers resistance to various anticancer drugs. We show …

The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a
major role in the regulation of BA and lipid metabolism. Recently, several studies have …

Plasma HDL cholesterol levels are inversely related to risk for atherosclerosis. The ATP-binding
cassette, subfamily A, member 1 (ABCA1) mediates the rate-controlling step in HDL …

The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid
metabolism; activation of LXR induces transcription of lipogenic genes. This study shows that …

Bile acids are the end products of cholesterol metabolism. They are synthesized in the liver
and secreted via bile into the intestine, where they aid in the absorption of fat-soluble …

Proteins secreted from adipose tissue are increasingly recognized to play an important role
in the regulation of glucose metabolism. However, much less is known about their effect on …

The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual’s genetics and the composition of their diet and gut microbiome. …

Over the past decade, it has become apparent that bile acids are involved in a host of activities
beyond their classic functions in bile formation and fat absorption. The identification of the …