[HTML][HTML] Single-nucleus and in situ RNA–sequencing reveal cell topographies in the human pancreas
Background and aims Molecular evidence of cellular heterogeneity in the human exocrine
pancreas has not been yet established, due to the local concentration and cascade of …
pancreas has not been yet established, due to the local concentration and cascade of …
[HTML][HTML] Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
TG Krieger, S Le Blanc, J Jabs, FW Ten… - Nature …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished ‘classical’ from ‘…
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished ‘classical’ from ‘…
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19
…, RL Chua, V Farztdinov, S Lukassen, FW Ten… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
The central nervous system's proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2
…, RL Chua, V Farztdinov, S Lukkassen, FW Ten… - medRxiv, 2023 - medrxiv.org
In COVID-19 neurological alterations are noticed during the systemic viral infection. Various
pathophysiological mechanisms on the central nervous system (CNS) have been suggested …
pathophysiological mechanisms on the central nervous system (CNS) have been suggested …
[HTML][HTML] Functional states in tumor-initiating cell differentiation in human colorectal cancer
…, TG Krieger, A Oberlack, RL Chua, M Huerta, FW Ten… - Cancers, 2021 - mdpi.com
Simple Summary Different types of cells with tumor-initiating cell (TIC) activity contribute to
colorectal cancer (CRC) progression and resistance to anti-cancer treatment. In this study, we …
colorectal cancer (CRC) progression and resistance to anti-cancer treatment. In this study, we …
Gene set inference from single-cell sequencing data using a hybrid of matrix factorization and variational autoencoders
S Lukassen, FW Ten, L Adam, R Eils… - Nature Machine …, 2020 - nature.com
Recent advances in single-cell RNA sequencing have driven the simultaneous measurement
of the expression of thousands of genes in thousands of single cells. These growing …
of the expression of thousands of genes in thousands of single cells. These growing …
[HTML][HTML] resVAE ensemble: Unsupervised identification of gene sets in multi-modal single-cell sequencing data using deep ensembles
Feature identification and manual inspection is currently still an integral part of biological
data analysis in single-cell sequencing. Features such as expressed genes and open …
data analysis in single-cell sequencing. Features such as expressed genes and open …
Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids
…, J Jabs, T Bauer, S Schuth, Q Hu, O Debnath, FW Ten… - bioRxiv, 2021 - biorxiv.org
Pancreatic ductal adenocarcinoma (PDAC) is characterized by high drug resistance and
poor prognosis. Novel therapeutic and stratification strategies are urgently needed. Here, we …
poor prognosis. Novel therapeutic and stratification strategies are urgently needed. Here, we …
The central nervous systems proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2 (preprint)
…, RL Chua, V Farztdinov, S Lukkassen, FW Ten… - 2023 - pesquisa.bvsalud.org
In COVID-19 neurological alterations are noticed during the systemic viral infection. Various
pathophysiological mechanisms on the central nervous system (CNS) have been suggested …
pathophysiological mechanisms on the central nervous system (CNS) have been suggested …
Transcriptional heterogeneity identifies functional states of tumor-initiating cell differentiation in human colorectal cancer
…, T Krieger, A Oberlack, RL Chua, M Huerta, FW Ten… - Cancer Research, 2020 - AACR
Tumor progression in colorectal cancer (CRC) is driven by a subpopulation of cells with
tumor-initiating cell (TIC) activity. In the past, bulk experiments provided strong evidence for …
tumor-initiating cell (TIC) activity. In the past, bulk experiments provided strong evidence for …