The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
Huntington’s disease is a neurodegenerative disorder caused by a CAG expansion in the
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin (…
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin (…
[PDF][PDF] Flanking regions determine the structure of the poly-glutamine in huntingtin through mechanisms common among glutamine-rich human proteins
…, CA Elena-Real, P Mier, A Fournet, F Allemand… - Structure, 2020 - cell.com
The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal
region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich …
region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich …
Combiningdry'co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography
M Gelin, V Delfosse, F Allemand, F Hoh… - … Section D: Biological …, 2015 - scripts.iucr.org
X-ray crystallography is an established technique for ligand screening in fragment-based
drug-design projects, but the required manual handling steps – soaking crystals with ligand …
drug-design projects, but the required manual handling steps – soaking crystals with ligand …
Discovery of a cryptic site at the interface 2 of TEAD–Towards a new family of YAP/TAZ-TEAD inhibitors
…, P Melnyk, M Gelin, F Allemand… - European Journal of …, 2021 - Elsevier
The Hippo pathway is involved in organ size control and tissue homeostasis by regulating
cell growth, proliferation and apoptosis. It controls the phosphorylation of the transcription co-…
cell growth, proliferation and apoptosis. It controls the phosphorylation of the transcription co-…
[HTML][HTML] Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
…, E Villain, A Fournet, M Kazantseva, F Allemand… - Nature …, 2021 - nature.com
The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β
activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates …
activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates …
[PDF][PDF] Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation
C Lecointre, V Simon, C Kerneur, F Allemand… - Structure, 2018 - cell.com
The pseudo-kinase and signaling protein Pragmin has been linked to cancer by regulating
protein tyrosine phosphorylation via unknown mechanisms. Here we present the crystal …
protein tyrosine phosphorylation via unknown mechanisms. Here we present the crystal …
Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1
…, A Sagar, A Fournet, A Estaña, T Bellande, F Allemand… - Structure, 2023 - cell.com
Huntington's disease neurodegeneration occurs when the number of consecutive
glutamines in the huntingtin exon-1 (HTTExon1) exceeds a pathological threshold of 35. The …
glutamines in the huntingtin exon-1 (HTTExon1) exceeds a pathological threshold of 35. The …
A general strategy to access structural information at atomic resolution in polyglutamine homorepeats
A Urbanek, A Morató, F Allemand… - Angewandte …, 2018 - Wiley Online Library
Homorepeat (HR) proteins are involved in key biological processes and multiple pathologies,
however their high‐resolution characterization has been impaired due to their homotypic …
however their high‐resolution characterization has been impaired due to their homotypic …
Cold adaptation in DEAD-box proteins
G Cartier, F Lorieux, F Allemand, M Dreyfus… - Biochemistry, 2010 - ACS Publications
Spontaneous rearrangements of RNA structures are usually characterized by large activation
energies and thus become very slow at low temperatures, yet RNA structure must remain …
energies and thus become very slow at low temperatures, yet RNA structure must remain …
Evidence of the reduced abundance of proline cis conformation in protein poly proline tracts
…, A Estaña, A Fournet, F Allemand… - Journal of the …, 2020 - ACS Publications
Proline is found in a cis conformation in proteins more often than other proteinogenic amino
acids, where it influences structure and modulates function, being the focus of several high-…
acids, where it influences structure and modulates function, being the focus of several high-…