The biology of mitochondrial uncoupling proteins

…, B Miroux, AM Cassard-Doulcier, F Bouillaud… - Diabetes, 2004 - Am Diabetes Assoc
Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner membrane
of mitochondria. They are found in all mammals and in plants. They belong to the family of …

[HTML][HTML] DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade

…, KA Olaussen, L Friboulet, F Bouillaud… - The Journal of …, 2018 - Am Soc Clin Investig
Synthetic lethality is an efficient mechanism-based approach to selectively target DNA repair
defects. Excision repair cross-complementation group 1 (ERCC1) deficiency is frequently …

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

…, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud… - Nature …, 2000 - nature.com
The gene Ucp2 is a member of a family of genes found in animals and plants, encoding a
protein homologous to the brown fat uncoupling protein Ucp1 (refs 1–3). As Ucp2 is widely …

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

…, G Olah, K Yanagi, F Bouillaud - British journal of …, 2014 - Wiley Online Library
Until recently, hydrogen sulfide ( H 2 S ) was exclusively viewed a toxic gas and an environmental
hazard, with its toxicity primarily attributed to the inhibition of mitochondrial C omplex …

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

…, P Radermacher, F Bouillaud… - British journal of …, 2014 - Wiley Online Library
Emerging work demonstrates the dual regulation of mitochondrial function by hydrogen sulfide
( H 2 S ), including, at lower concentrations, a stimulatory effect as an electron donor, and, …

[HTML][HTML] Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis

…, A Olivier-Bandini, J Bellalou, E Moyse, F Bouillaud… - Cell, 2015 - cell.com
Rod-derived cone viability factor (RdCVF) is an inactive thioredoxin secreted by rod
photoreceptors that protects cones from degeneration. Because the secondary loss of cones in …

Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

D Ricquier, F Bouillaud - The Journal of physiology, 2000 - Wiley Online Library
The coupling of oxygen consumption to ADP phosphorylation is incomplete, as is particularly
evident in brown adipocyte mitochondria which use a regulated uncoupling mechanism to …

[HTML][HTML] Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation

…, E Couplan, S Collins, D Ricquier, F Bouillaud… - Journal of Biological …, 2001 - ASBMB
Uncoupling protein 2 (UCP2) belongs to the mitochondrial anion carrier family and partially
uncouples respiration from ATP synthesis when expressed in recombinant yeast …

[HTML][HTML] Acquirement of brown fat cell features by human white adipocytes

…, G Tavernier, C Lefort, D Larrouy, F Bouillaud… - Journal of Biological …, 2003 - ASBMB
Obesity, ie an excess of white adipose tissue (WAT), predisposes to the development of type
2 diabetes and cardiovascular disease. Brown adipose tissue is present in rodents but not …

Sulfide, the first inorganic substrate for human cells

…, T Nübel, F Blachier, F Bouillaud - The FASEB …, 2007 - Wiley Online Library
Hydrogen sulfide (H 2 S) is produced inside the intestine and is known as a poison that
inhibits cellular respiration at the level of cytochrome oxidase. However, sulfide is used as an …