The subdivision of the embryo into physically distinct regions is one of the most fundamental
processes in development. General hypotheses for tissue separation based on differential …

Knowledge of when and where signaling pathways are activated is crucial for understanding
embryonic development. In this study, we have systematically analyzed and compared the …

After two decades of stardom, one would think that β‐catenin has revealed all of its most
intimate details. Yet the essence of its duality has remained mysterious—how can a single …

Mutations at the mouse Fused locus have pleiotropic developmental effects, including the
formation of axial duplications in homozygous embryos. The product of the Fused locus, Axin, …

Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries.
The complexity of the system is puzzling, however in many instances, tissues express …

Background The primordial organization of the metazoan body is achieved during
gastrulation by the establishment of the germ layers. Adhesion differences between ectoderm, …

Axin is a negative regulator of the Wnt pathway essential for down-regulation of β-catenin.
Axin has been considered so far as a cytoplasmic protein. Here we show that, although …

The mechanism responsible for subdividing the embryo into individual tissues is a
fundamental, yet still poorly understood, question in developmental biology. Various general …

… Using semipermeabilized oocytes, we were able to demonstrate the activity of a vacuolar
proton pump in the YGs, and we found that YG pH is sensitive to cytoplasmic factors, since …

Background: Control of the nuclear localization of specific proteins is an important mechanism
for regulating many signal transduction pathways. Upon activation of the Wnt signaling …