[HTML][HTML] Molecular minimal residual disease in acute myeloid leukemia
…, T Grob, D Hanekamp, FG Kavelaars… - … England Journal of …, 2018 - Mass Medical Soc
Background Patients with acute myeloid leukemia (AML) often reach complete remission, but
relapse rates remain high. Next-generation sequencing enables the detection of molecular …
relapse rates remain high. Next-generation sequencing enables the detection of molecular …
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
S Abbas, S Lugthart, FG Kavelaars… - Blood, The Journal …, 2010 - ashpublications.org
Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently
demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact …
demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact …
Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome
…, MA Sanders, FG Kavelaars… - Blood, The Journal …, 2022 - ashpublications.org
Substantial heterogeneity within mutant TP53 acute myeloid leukemia (AML) and
myelodysplastic syndrome with excess of blast (MDS-EB) precludes the exact assessment of …
myelodysplastic syndrome with excess of blast (MDS-EB) precludes the exact assessment of …
[HTML][HTML] Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value
…, MA Sanders, JE Koenders, FG Kavelaars… - …, 2012 - ncbi.nlm.nih.gov
Somatic mutations in the additional sex comb-like 1 (ASXL1) gene have been described in
various types of myeloid malignancies, including acute myeloid leukemia. Analysis of novel …
various types of myeloid malignancies, including acute myeloid leukemia. Analysis of novel …
MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML
…, RM Hoogenboezem, FG Kavelaars… - Blood, The Journal …, 2018 - ashpublications.org
The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a
major role in shaping the human genome, and this methylation damage remains the primary …
major role in shaping the human genome, and this methylation damage remains the primary …
Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia
…, T Grob, RM Hoogenboezem, FG Kavelaars… - Cancer discovery, 2021 - AACR
We show a novel paradigm in which chromosomal aberrations reveal critical regulatory
elements that are nonfunctional at their endogenous locus. This knowledge provides a rationale …
elements that are nonfunctional at their endogenous locus. This knowledge provides a rationale …
Detecting measurable residual disease beyond 10−4 by an IGHV leader-based NGS approach improves prognostic stratification in CLL
…, MY van der Klift, PM Kolijn, F Davi, FG Kavelaars… - Blood, 2023 - ashpublications.org
The sensitivity of conventional techniques for reliable quantification of minimal/measurable
residual disease (MRD) in chronic lymphocytic leukemia (CLL) is limited to MRD 10 −4 . …
residual disease (MRD) in chronic lymphocytic leukemia (CLL) is limited to MRD 10 −4 . …
RUNX1 germline variants in RUNX1-mutant AML: how frequent?
MPT Ernst, FG Kavelaars, B Löwenberg… - Blood, The Journal …, 2021 - ashpublications.org
RUNX1 mutations are recurrent aberrations in acute myeloid leukemia (AML) that are either
somatically acquired or originate in the germline. Monoallelic pathogenic germline RUNX1 …
somatically acquired or originate in the germline. Monoallelic pathogenic germline RUNX1 …
[HTML][HTML] Next-generation sequencing analysis of the human TCRγδ+ T-cell repertoire reveals shifts in Vγ-and Vδ-usage in memory populations upon aging
MJ Kallemeijn, FG Kavelaars, MY van der Klift… - Frontiers in …, 2018 - frontiersin.org
Immunological aging remodels the immune system at several levels. This has been
documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced …
documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced …
[HTML][HTML] Delineating human B cell precursor development with genetically identified PID cases as a model
…, L del Pino Molina, H IJspeert, FG Kavelaars… - Frontiers in …, 2019 - frontiersin.org
B-cell precursors (BCP) arise from hematopoietic stem cells in bone marrow (BM). Identification
and characterization of the different BCP subsets has contributed to the understanding of …
and characterization of the different BCP subsets has contributed to the understanding of …