Background Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with
heterogeneous clinical outcomes. Several molecular classifications have been proposed, but …

In a transgenic mouse model, dermal fibrosarcomas develop in a pathway comprised of at
least three stages: mild fibromatosis, aggressive fibromatosis, and fibrosarcoma. The latter …

Phospholipase A 2 activity can be determined fluorometrically in the presence of serum
albumin using phospholipids labeled at the sn-2-acyl position with 10-pyrenyldecanoic acid. In …

Tumour stage was defined using TNM and FIGO classifications for bladder and cervix carcinomas,
respectively; Mostofi’s histopathological grading system was used for bladder cancer; …

Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors
with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor …

Purpose: Fibroblast growth factor receptor 3 (FGFR3) mutations were recently found at a
high frequency in well-differentiated urothelial cell carcinoma (UCC). We investigated the …

We analyzed the possible prognostic value of the recently discovered fibroblast growth factor
receptor 3 (FGFR3) mutations in bladder cancer. A FGFR3 mutation was found in 34 of 53 …

FGFR3 and TP53 mutations are frequent in superficial papillary and invasive disease,
respectively. We used denaturing high-performance liquid chromatography and sequencing to …

Genetic and epigenetic alterations have been identified that lead to transcriptional deregulation
in cancers. Genetic mechanisms may affect single genes or regions containing several …

The advent of Omics technologies has been key to the molecular subclassification of urothelial
bladder cancer. Several groups have used different strategies to this aim, with partially …