Many successful vaccines induce persistent antibody responses that can last a lifetime. The
mechanisms by which they do so remain unclear, but emerging evidence indicates that they …

Understanding vaccine-elicited protection against SARS-CoV-2 variants and other
sarbecoviruses is key for guiding public health policies. We show that a clinical stage multivalent …

The development of a portfolio of COVID-19 vaccines to vaccinate the global population
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …

Heterologous prime/boost regimens have the potential for raising high levels of immune
responses. Here we report that DNA priming followed by a recombinant modified vaccinia …

To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization
strategies are needed that elicit protection at mucosal portals of pathogen entry. Immunization …

The administration of antigens in soluble form can induce antigen-specific immune tolerance
and suppress experimental autoimmune diseases. In a marmoset model of multiple …

Although antivirals are important tools to control severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, effective vaccines are essential to control the current …

Cytokines play a central role in the pathogenesis of many diseases, including HIV infection.
However, the role of the cytokine network in early HIV infection is only now starting to be …

Background Dengue is one of the fastest spreading vector-borne diseases, caused by four
antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for …

Antibodies and cytotoxic T cells represent 2 arms of host defense against pathogens. We
hypothesized that vaccines that induce both high-magnitude CD8+ T cell responses and …