Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression

FX Blaudin de Thé, H Rekaik, E Peze‐Heidsieck… - The EMBO …, 2018 - embopress.org
the expression of Piwi genes in the same tissues (Fig 1H). Piwil1, 2, and 4 are expressed
at extremely low levels compared to the expression in the testis (logarithmic scale). The

[HTML][HTML] Dissecting the role of Engrailed in adult dopaminergic neurons–Insights into Parkinson disease pathogenesis

H Rekaik, FXB de Thé, A Prochiantz, J Fuchs, RL Joshi - FEBS letters, 2015 - Elsevier
the homeoprotein Engrailed, which belongs to the class of DNA binding homeodomain
containing transcription factors. The … patch of cells in the anterior neuroepithelium in the midbrain …

[HTML][HTML] P62 accumulates through neuroanatomical circuits in response to tauopathy propagation

FX Blaudin de Thé, B Lassus, AW Schaler… - Acta Neuropathologica …, 2021 - Springer
… of tau in the donor chamber led to tau pathology spread and p62 accumulation in … the donor
and the recipient chamber. Overall, these data are in accordance with the hypothesis that the

Transforming drug discovery with a high-throughput AI-powered platform: A 5-year experience with Patrimony

FXB de Thé, C Baudier, RA Pereira, C Lefebvre… - Drug Discovery …, 2023 - Elsevier
… based on a deep understanding of the pathophysiology of immuno-inflammatory diseases.
the platform and broadening its applications to neurological diseases. We emphasize the

[HTML][HTML] Model Identifies Genetic Predisposition of Alzheimer's Disease as Key Decider in Cell Susceptibility to Stress

IC Stefani, FXB de Thé, C Kontoravdi… - International Journal of …, 2021 - mdpi.com
the highest global response. We further developed a dynamic mathematical model of the
UPR that describes the activation of the … of the experimental data suggests that the mutant cell …

[CITATION][C] Engrailed, an Anti-ageing Homeoprotein

Francois-Xavier Blaudin de Thé - 2015

[CITATION][C] François-Xavier Blaudin de Thé, Julia Fuchs, Olivia Massiani-Beaudoin, Alain Prochiantz, and Rajiv L Joshi. 2015.“Engrailed Homeoprotein Protects …

H Rekaik - Cell Reports

[PDF][PDF] Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress

H Rekaik, J Fuchs, O Massiani-Beaudoin, A Prochiantz… - Cell reports, 2015 - cell.com
… find that the loss of one En1 allele leads to changes in the … 6 hr, the loss of 35% of the TH+
neurons and the formation of … of the remaining ones (Figures 2A and 2B), only in the ipsilateral …

A new PERKspective on neurodegeneration

W Scheper, JJM Hoozemans - Science Translational Medicine, 2013 - science.org
the assembly of the ribosome with mRNA and the initiation of translation. Phosphorylation of
eIF2α prevents the formation of this ternary complex, resulting in the … control the synthesis of …

[HTML][HTML] Neuroprotective transcription factors in animal models of Parkinson disease

H Rekaik, A Prochiantz, J Fuchs, RL Joshi - Neural plasticity, 2016 - hindawi.com
… disease is that nonnigral dopaminergic neurons including mDA neurons in the ventral
tegmental area (VTA), located in the vicinity of the SNpc mDA neurons, are relatively spared. …