Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
might be curtailed by vaccination. We assessed the safety, reactogenicity, and …

(1) A preparation is described which allows patch clamp recordings to be made on mammalian
central nervous system (CNS) neurones in situ. (2) A vibrating tissue slicer was used to …

UNTIL now, the only well documented, fast excitatory neurotrans-mitter in the brain has been
glutamate. Although there is evidence for adenosine 5′-triphosphate (ATP) acting as a …

Despite their wide use, the physiological relevance of organotypic slices remains controversial.
Such cultures are prepared at 5 days postnatal. Although some local circuitry remains …

Background Neural stem cells (NSCs) are powerful research tools for the design and
discovery of new approaches to neurodegenerative disease. Overexpression of the myc family …

We provide microarray data comparing genome-wide differential expression and pathology
throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP…

1. Synaptically connected neurones were identified in the granule cell layer of slices of 17‐
to 21‐day‐old rat hippocampus. Whole‐cell current recording using the patch‐clamp …

Evidence suggests that amyloid β is highly toxic to synapses in a phospho-Tau-dependent
manner. Here, I present a hypothesis that links previous evidence from the first rise of amyloid …

Genome-wide association studies have reported that, amongst other microglial genes, variants
in TREM2 can profoundly increase the incidence of developing Alzheimer’s disease (AD)…

Detecting and treating Alzheimer’s disease, before cognitive deficits occur, has become the
health challenge of our time. The earliest known event in Alzheimer’s disease is rising …