Cell-cell signalling of semaphorin ligands through interaction with plexin receptors is important
for the homeostasis and morphogenesis of many tissues and is widely studied for its role …

According to the general understanding, the chondrocyte lineage terminates with the elimination
of late hypertrophic cells by apoptosis in the growth plate. However, recent cell tracking …

Hereditary spastic paraplegias are a group of inherited motor neuron diseases characterized
by progressive paraparesis and spasticity. Mutations in the spastic paraplegia gene SPG11…

The development of the nervous system (NS) requires the coordinated migration of multiple
waves of neurons and subsequent processes of neurite maturation, both involving selective …

Directed cell migration and axonal guidance are essential steps in neural development. Both
processes are controlled by specific guidance cues that activate the signaling cascades …

In many societies, the majority of adults regularly consume alcohol. However, only a small
proportion develops alcohol addiction. Individuals at risk often show a high sensation-seeking/…

Objective Mutations in the spastic paraplegia gene 11 (SPG11), encoding spatacsin, cause
the most frequent form of autosomal‐recessive complex hereditary spastic paraplegia (HSP) …

… Francesc Perez-Branguli; Francesc Perez-Branguli … Tobias Rothe, Natacha Ipseiz, Maria
Faas, Stefanie Lang, Francesc Perez-Branguli, Daniel Metzger, Hiroshi Ichinose, Beate Winner, …

Spastic paraplegia gene 11(SPG11)-linked hereditary spastic paraplegia is a complex
monogenic neurodegenerative disease that in addition to spastic paraplegia is characterized by …

The transmembrane semaphorin, Sema6A, has important roles in axon guidance, cell migration
and neuronal connectivity in multiple regions of the nervous system, mediated by context…