User profiles for Francesca Chiaromonte
Francesca ChiaromonteProfessor of Statistics, Pennsylvania State University, Sant'Anna School of Advanced … Verified email at psu.edu Cited by 22578 |
Scoring pairwise genomic sequence alignments
F Chiaromonte, VB Yap, W Miller - Biocomputing 2002, 2001 - World Scientific
The parameters by which alignments are scored can strongly affect sensitivity and specificity
of alignment procedures. While appropriate parameter choices are well understood for …
of alignment procedures. While appropriate parameter choices are well understood for …
[HTML][HTML] Complete Khoisan and Bantu genomes from southern Africa
The genetic structure of the indigenous hunter-gatherer peoples of southern Africa, the oldest
known lineage of modern human, is important for understanding human diversity. Studies …
known lineage of modern human, is important for understanding human diversity. Studies …
Contour regression: a general approach to dimension reduction
We propose a novel approach to sufficient dimension reduction in regression, based on
estimating contour directions of small variation in the response. These directions span the …
estimating contour directions of small variation in the response. These directions span the …
[HTML][HTML] Qualitative network models and genome-wide expression data define carbon/nitrogen-responsive molecular machines in Arabidopsis
RA Gutiérrez, LV Lejay, A Dean, F Chiaromonte… - Genome biology, 2007 - Springer
Background Carbon (C) and nitrogen (N) metabolites can regulate gene expression in
Arabidopsis thaliana. Here, we use multinetwork analysis of microarray data to identify molecular …
Arabidopsis thaliana. Here, we use multinetwork analysis of microarray data to identify molecular …
Evidence for sharp increase in the economic damages of extreme natural disasters
Climate change has increased the frequency and intensity of natural disasters. Does this
translate into increased economic damages? To date, empirical assessments of damage trends …
translate into increased economic damages? To date, empirical assessments of damage trends …
The genome-wide determinants of human and chimpanzee microsatellite evolution
YD Kelkar, S Tyekucheva, F Chiaromonte… - Genome …, 2008 - genome.cshlp.org
Mutation rates of microsatellites vary greatly among loci. The causes of this heterogeneity
remain largely enigmatic yet are crucial for understanding numerous human neurological …
remain largely enigmatic yet are crucial for understanding numerous human neurological …
Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution
Six measures of evolutionary change in the human genome were studied, three derived
from the aligned human and mouse genomes in conjunction with the Mouse Genome …
from the aligned human and mouse genomes in conjunction with the Mouse Genome …
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression
The transcription factor GATA1 regulates an extensive program of gene activation and
repression during erythroid development. However, the associated mechanisms, including the …
repression during erythroid development. However, the associated mechanisms, including the …
Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA
…, TS Korneliussen, F Chiaromonte… - Proceedings of the …, 2014 - National Acad Sciences
The manifestation of mitochondrial DNA (mtDNA) diseases depends on the frequency of
heteroplasmy (the presence of several alleles in an individual), yet its transmission across …
heteroplasmy (the presence of several alleles in an individual), yet its transmission across …
Envelope models for parsimonious and efficient multivariate linear regression
We propose a new parsimonious version of the classical multivariate normal linear model,
yielding a maximum likelihood estimator (MLE) that is asymptotically less variable than the …
yielding a maximum likelihood estimator (MLE) that is asymptotically less variable than the …