[HTML][HTML] Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled …

…, C Di Maso, I Dietrich, T Dong, FR Donnellan… - The Lancet, 2020 - thelancet.com
Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
might be curtailed by vaccination. We assessed the safety, reactogenicity, and …

[HTML][HTML] Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials …

…, T Demissie, C Di Maso, T Dinesh, FR Donnellan… - The Lancet, 2021 - thelancet.com
Background COVID-19 vaccine supply shortages are causing concerns about compromised
immunity in some countries as the interval between the first and second dose becomes …

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

…, JD Allen, H Chawla, D Pulido, F Donnellan… - ACS central …, 2021 - ACS Publications
Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the
neutralizing immune response, the spike (S) glycoprotein. Adenovirus-vectored vaccines offer …

[PDF][PDF] Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies

…, R Kumarasingha, S Mehmood, FR Donnellan… - Cell, 2019 - cell.com
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading
target for next-generation vaccines against the disease-causing blood-stage of malaria. …

[PDF][PDF] Therapeutic monoclonal antibodies for Ebola virus infection derived from vaccinated humans

…, CJ Cherry, J Jin, GM Labbé, FR Donnellan… - Cell reports, 2019 - cell.com
We describe therapeutic monoclonal antibodies isolated from human volunteers vaccinated
with recombinant adenovirus expressing Ebola virus glycoprotein (EBOV GP) and boosted …

Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

RJ Ragotte, D Pulido, FR Donnellan, ML Hill, G Gorini… - MSphere, 2021 - Am Soc Microbiol
Basigin, or CD147, has been reported as a coreceptor used by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) to invade host cells. Basigin also has a well-established …

[HTML][HTML] The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 beta (B. 1.351) and other variants of concern in preclinical …

…, J Mongkolsapaya, H Davies, FR Donnellan… - …, 2022 - thelancet.com
Background There is an ongoing global effort to design, manufacture, and clinically assess
vaccines against SARS-CoV-2. Over the course of the ongoing pandemic a number of new …

[HTML][HTML] A review of broadly protective monoclonal antibodies to treat Ebola virus disease

P Rijal, FR Donnellan - Current Opinion in Virology, 2023 - Elsevier
… Author links open overlay panel Pramila Rijal 1 2 * , Francesca R. Donnellan 3 4 * …

Antibodies as drugs—a Keystone Symposia report

…, MA Sleeman, N Pengo, FR Donnellan - Annals of the New …, 2023 - Wiley Online Library
Therapeutic antibodies have broad indications across diverse disease states, such as
oncology, autoimmune diseases, and infectious diseases. New research continues to identify …

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

…, P Kirtley, L Picard, CD Wiggins, FR Donnellan… - bioRxiv, 2023 - biorxiv.org
The highly conserved and essential Plasmodium falciparum reticulocyte-binding protein
homolog 5 (PfRH5) has emerged as the leading target for vaccines that seek to protect against …