[PDF][PDF] C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
…, J Lum, I Low, EC Forsberg, M Poidinger, F Zolezzi… - Immunity, 2015 - cell.com
Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from
embryonic precursors that seed the tissues prior to birth to generate a self-renewing population…
embryonic precursors that seed the tissues prior to birth to generate a self-renewing population…
Identification of cDC1-and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
…, J Lum, B Malleret, S Zhang, A Larbi, F Zolezzi… - Nature …, 2015 - nature.com
Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct
lineages: the CD8α + (CD103 + ) cDC1 lineage, and the CD11b + cDC2 lineage. cDCs arise …
lineages: the CD8α + (CD103 + ) cDC1 lineage, and the CD11b + cDC2 lineage. cDCs arise …
Metformin as adjunct antituberculosis therapy
The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential
new approach to TB therapy is to augment protective host immune responses. We report …
new approach to TB therapy is to augment protective host immune responses. We report …
Mapping the human DC lineage through the integration of high-dimensional techniques
…, I Low, NB Shadan, CFS Fen, A Tay, J Lum, F Zolezzi… - Science, 2017 - science.org
INTRODUCTION Dendritic cells (DC) are professional antigen-presenting cells that orchestrate
immune responses. The human DC population comprises multiple subsets, including …
immune responses. The human DC population comprises multiple subsets, including …
[HTML][HTML] Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire
…, A Tschumi, B Lee, M Poidinger, F Zolezzi… - Nature …, 2014 - nature.com
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic …
conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic …
[PDF][PDF] Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression
…, L Raman, J Lum, TP Thamboo, E Chiong, F Zolezzi… - Immunity, 2014 - cell.com
Monocytes and macrophages are major components of the tumor microenvironment, but
their contributions to human cancer are poorly understood. We used molecular profiling …
their contributions to human cancer are poorly understood. We used molecular profiling …
Experimental evolution of a fungal pathogen into a gut symbiont
…, M Yurieva, W Liao, M Poidinger, F Zolezzi… - Science, 2018 - science.org
Gut microbes live in symbiosis with their hosts, but how mutualistic animal-microbe interactions
emerge is not understood. By adaptively evolving the opportunistic fungal pathogen …
emerge is not understood. By adaptively evolving the opportunistic fungal pathogen …
[HTML][HTML] IgG1 memory B cells keep the memory of IgE responses
…, J Lum, A Lee, J Chen, M Poidinger, F Zolezzi… - Nature …, 2017 - nature.com
The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory.
IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE …
IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE …
[PDF][PDF] Gene essentiality is a quantitative property linked to cellular evolvability
…, J Liu, JSY Lim, M Poidinger, GD Wright, F Zolezzi… - Cell, 2015 - cell.com
Gene essentiality is typically determined by assessing the viability of the corresponding
mutant cells, but this definition fails to account for the ability of cells to adaptively evolve to …
mutant cells, but this definition fails to account for the ability of cells to adaptively evolve to …
Functionally diverse human T cells recognize non-microbial antigens presented by MR1
10.7554/eLife.24476.001 MHC class I-related molecule MR1 presents riboflavin- and folate-related
metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 …
metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 …