Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra- or extra-cellular conditions. Structurally, they are rich in …

Owing to their outstanding performances in molecular recognition, antibodies are extensively
used in research and applications in molecular biology, biotechnology and medicine. …

It is generally recognized that a large fraction of the human proteome is made up of proteins
that remain disordered in their native states. Despite the fact that such proteins play key …

Here, we use single-molecule techniques to study the aggregation of α-synuclein, the protein
whose misfolding and deposition is associated with Parkinson's disease. We identify a …

We describe the isolation and detailed structural characterization of stable toxic oligomers of
α-synuclein that have accumulated during the process of amyloid formation. Our approach …

Protein solubility is often an essential requirement in biotechnological and biomedical
applications. Great advances in understanding the principles that determine this specific property …

The self-assembly of α-synuclein is closely associated with Parkinson’s disease and related
syndromes. We show that squalamine, a natural product with known anticancer and antiviral …

Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures
of aggregate populations that are closely linked to neurodegenerative conditions, such as …

Antibodies targeting Aβ42 are under intense scrutiny because of their therapeutic potential
for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” …

Antibodies are powerful tools in life sciences research, as well as in diagnostic and
therapeutic applications, because of their ability to bind given molecules with high affinity and …