Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family, …

F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP)
but the mechanism(s) leading to channel formation remain undefined. Here, to shed light …

Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell
compartments, in order to finely adjust key biological routines to the fluctuating metabolic …

Mutations in neurofibromin, a Ras GTPase-activating protein, lead to the tumor predisposition
syndrome neurofibromatosis type 1. Here, we report that cells lacking neurofibromin …

Binding of the mitochondrial chaperone TRAP1 to client proteins shapes bioenergetic and
proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined. Here …

Cancer cells undergo changes in metabolic and survival pathways that increase their
malignancy. Isoform 2 of the glycolytic enzyme hexokinase ( HK 2) enhances both glucose …

SERPINB3 (SB3) is a serine protease inhibitor overexpressed in several malignancies of
epithelial origin, including primary liver cancer, where it inhibits apoptosis through poorly …

… Francesco Ciscato and Andrea Rasola performed and supervised the OCR experiments.
Stefania Bortoluzzi supervised bioinformatic analyses. Federica Lovisa and Lara Mussolin …

Transition metals offer many possibilities in developing potent chemotherapeutic agents.
They are endowed with a variety of oxidation states, allowing for the selection of their …

Background In the setting of liver injury hepatic progenitor cells are activated, counterbalancing
the inhibited regenerative capacity of mature hepatocytes. Chronic activation of this …