Tissue damage causes inflammation, by recruiting leukocytes and activating them to
release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) …

After tissue damage, inflammatory cells infiltrate the tissue and release proinflammatory
cytokines. HMGB1 (high mobility group box 1), a nuclear protein released by necrotic and …

Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark
of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking …

High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine
when released in the extracellular milieu by necrotic and inflammatory cells. Here, we show …

High-mobility group box 1 protein (HMGB1) is a nuclear component, but extracellularly it
serves as a signaling molecule involved in acute and chronic inflammation, for example in …

Tissue damage is usually followed by healing, as both differentiated and stem cells migrate
to replace dead or damaged cells. Mesoangioblasts (vessel-associated stem cells that can …

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and
treat. Here we describe the molecular, cellular and morphological characterization of a …

In response to endovascular injury, platelet-derived growth factor-BB (PDGF-BB) and basic
fibroblast growth factor (bFGF) are released locally and modulate vascular smooth muscle …

Inflammation and tissue regeneration follow tissue damage, but little is known about how these
processes are coordinated. High Mobility Group Box 1 (HMGB1) is a nuclear protein that, …

Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever
and inflammation. In addition, prophylactic use of acetylsalicylic acid, commonly known as …