Although progesterone has been recognized as essential for the establishment and maintenance
of pregnancy, this steroid hormone has been recently implicated to have a functional …

Candidate transcription factors involved in pancreatic endocrine development have been
isolated using insulin gene regulation as a paradigm. The cell-type restricted basic helix–loop–…

Knockout mouse technology has been used over the last decade to define the essential roles
of ovarian-expressed genes and uncover genetic interactions. In particular, we have used …

Progesterone regulates reproductive function through two intracellular receptors, progesterone
receptor–A (PR-A) and progesterone receptor–B (PR-B), that arise from a single gene …

Development of stratified epithelia, such as the epidermis, requires p63 expression. The
p63 gene encodes isoforms that contain (TA) or lack (ΔN) a transactivation domain. We …

The in vivo biological function of a steroid receptor coactivator was assessed in mice in
which the SRC-1 gene was inactivated by gene targeting. Although in both sexes the …

Steroid receptor RNA activator (SRA) is an RNA that coactivates steroid hormone receptor-mediated
transcription in vitro. Its expression is strongly up-regulated in many human tumors …

We have previously reported the development of a transgenic mouse model for prostate
cancer derived from PB-Tag transgenic line 8247, henceforth designated the TRAMP (…

Arteries and veins are anatomically, functionally and molecularly distinct. The current model
of arterial–venous identity proposes that binding of vascular endothelial growth factor to its …

Progesterone (P) regulates female reproduction via two nuclear receptors, PR-A and PR-B.
Although both receptors display overlapping and distinct transcription regulatory properties, …