Renal amyloidosis is a rare condition caused by the progressive accumulation of misfolded
proteins within glomeruli, vessels, and interstitium, causing functional decline and requiring …

The estimation of tumor cellular fraction (TCF) is a crucial step in predictive molecular pathology,
representing an entry adequacy criterion also in the next-generation sequencing (NGS) …

Immunodetection on mouse routinely processed tissue via antibodies raised in mice faces
cross-reactivity of the secondary anti-mouse reagents with endogenous immunoglobulins, …

Antigen-bearing proteins become progressively unavailable to immunodetection after
prolonged storage of routine sections, exposed to a variety of agents, such as moisture, oxygen, …

Aim The digital transformation of the pathology laboratory is being continuously sustained
by the introduction of innovative technologies promoting whole slide image (WSI)-based …

Background: Antibody validation for tissue staining is required for reproducibility; criteria to
ensure validity have been published recently. The majority of these recommendations imply …

Colon adenocarcinoma (COAD) has a limited range of diversified, personalized therapeutic
opportunities, besides DNA hypermutating cases; thus, both new targets or broadening …

Colon adenocarcinoma (COAD) has a limited range of diversified, personalized therapeutic
opportunities, besides DNA hypermutating cases; thus both new targets or broadening …

A customized context-dependent validation of antibodies for the prospective use, rather than
a general stamp of validity, is required for reproducibility and data validity, besides the need …

Background: Antibody validation for tissue staining is required for reproducibility and criteria
to ensure validity have been published recently. The majority of these recommendations …