The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and
post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using …

Abstract Analysis of mutational signatures is becoming routine in cancer genomics, with
implications for pathogenesis, classification, prognosis, and even treatment decisions. However, …

All normal somatic cells are thought to acquire mutations, but understanding of the rates,
patterns, causes and consequences of somatic mutations in normal cells is limited. The uterine …

The evolution and progression of multiple myeloma and its precursors over time is poorly
understood. Here, we investigate the landscape and timing of mutational processes shaping …

Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short
arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole …

B cell maturation antigen (BCMA) target loss is considered to be a rare event that mediates
multiple myeloma (MM) resistance to anti-BCMA chimeric antigen receptor T cell (CAR T) or …

Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL)
into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …

About half of all cancers have somatic integrations of retrotransposons. Here, to characterize
their role in oncogenesis, we analyzed the patterns and mechanisms of somatic …

We analyzed whole genomes of unique paired samples from smoldering multiple myeloma (SMM)
patients progressing to multiple myeloma (MM). We report that the genomic landscape…

In multiple myeloma, next-generation sequencing (NGS) has expanded our knowledge of
genomic lesions, and highlighted a dynamic and heterogeneous composition of the tumor. …