AIRE deficiency, from preclinical models to human APECED disease

M Besnard, F Padonou, N Provin… - Disease models & …, 2021 - journals.biologists.com
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare life-threatening
autoimmune disease that attacks multiple organs and has its onset in childhood. …

Aire-dependent genes undergo Clp1-mediated 3'UTR shortening associated with higher transcript stability in the thymus

C Guyon, N Jmari, F Padonou, YC Li, O Ucar… - Elife, 2020 - elifesciences.org
The ability of the immune system to avoid autoimmune disease relies on tolerization of
thymocytes to self-antigens whose expression and presentation by thymic medullary epithelial …

Aire‐dependent transcripts escape Raver2‐induced splice‐event inclusion in the thymic epithelium

F Padonou, V Gonzalez, N Provin, S Yayilkan… - EMBO …, 2022 - embopress.org
Aire allows medullary thymic epithelial cells (mTECs) to express and present a large number
of self‐antigens for central tolerance. Although mTECs express a high diversity of self‐…

Biomarkers and immunotherapy: where are we?

ML Fontsa, F Padonou… - Current Opinion in …, 2022 - journals.lww.com
Biomarkers and immunotherapy: where are we? : Current Opinion in Oncology Biomarkers and
immunotherapy: where are we? : Current Opinion in Oncology Log in or Register Subscribe to …

Can we yet use tertiary lymphoid structures as predictive biomarkers for immunotherapy response in melanoma?

F Padonou, T Vanhulst… - Current Opinion in …, 2024 - journals.lww.com
… Correspondence to Francine Padonou, PhD, Molecular Immunology, Laboratory, Institut
Jules Bordet, Université Libre de Bruxelles, Brussels, (1070 Anderlecht), Belgium. Tel: +32 …

Biomarkers of functionally active tertiary lymphoid structures in human breast cancer

D Sofronii, F Padonou, M Langouo, N Thomas… - Cancer Research, 2023 - AACR
The clinical relevance of tumor infiltrating lymphocytes (TIL) in breast cancer (BC) is now
widely accepted and being implemented in clinical practice. Our lab previously demonstrated …

Aire-dependent transcripts escape H3K36me3 and Raver2 induced alternative splicing to sustain central immune tolerance

F Padonou, V Gonzalez, N Jmari, J Maslovskaja… - bioRxiv, 2021 - biorxiv.org
Aire allows medullary thymic epithelial cells (mTECs) to express and present a large number
of self-antigens for central tolerance. Although mTECs express a high diversity of self-…

Single-cell profiling identifies clinically relevant interactions between tumor associated macrophages and blood endothelial cells in diffuse large B cell lymphoma

J Ferrant, S Le Gallou, F Padonou, S Léonard, I Papa… - bioRxiv, 2022 - biorxiv.org
Diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) are the two most common
B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B cells …

Biomarkers and immunotherapy: where are we?

F Padonou, K Willard-Gallo - Current Opinion in Oncology, 2022 - europepmc.org
Biomarkers and immunotherapy: where are we? - Abstract - Europe PMC Sign in | Create
an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact us …

Enhancing responses to cancer immunotherapy

P Kvistborg, JW Yewdell - Science, 2018 - science.org
Immune checkpoint blocking therapies (ICBs) that target T cell inhibitory receptors (immune
checkpoints) have been implemented in the clinic to treat a variety of malignancies. To …