Background: The circadian timing system controlled by the suprachiasmatic nuclei (SCN) of
the hypothalamus regulates daily rhythms of motor activity and adrenocortical secretion. An …

Background The efficacy of chemotherapy may be affected by circadian rhythms. Therefore,
we tested chronomodulated infusion (administered to coincide with relevant circadian …

The rest/activity circadian cycle has been used as a reference for chemotherapy administration
at specific times to improve tolerability and efficacy. Because cancer processes may be …

Objective: To evaluate the influence of the response to preoperative chemotherapy,
especially tumor progression, on the outcome following resection of multiple colorectal liver …

The circadian timing system is composed of molecular clocks, which drive 24-h changes in
xenobiotic metabolism and detoxification, cell cycle events, DNA repair, apoptosis, and …

BACKGROUND Cell physiology is regulated along the 24‐hour timescale by a circadian
clock, which is comprised of interconnected molecular loops involving at least nine genes. The …

The Working Group concluded there was limited evidence that night shift work causes breast,
prostate, and colorectal cancer. This evaluation was based on comprehensive searches of …

Les rythmes biologiques sont présents dans les règnes animal et végétal à tousles stades d’organisation,
de la cellule à l’organisme dans son entier. Lapréservation des rythmes …

In bone marrow transplantation, high-dose busulfan is given po, usually every 6 h over 4
consecutive days. Since this repeated administration might alter busulfan disposition, …

Background In a previous phase II trial, circadian (chrono-modulated) delivery of fluorouracil
(5-FU), folinic acid (FA; leucovorin), and oxaliplatin (1-OHP; a new platinum complex with …