Cholesterol is an integral component of eukaryotic cell membranes and a key molecule in
controlling membrane fluidity, organization, and other physicochemical parameters. It also …

The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems
is often hampered by issues such as poor circulation stability and targeting inefficiency. Here…

Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida
albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a …

Photodynamic therapy (PDT) and photothermal therapy (PTT) have gained considerable
attention as potential alternatives to conventional cancer treatments. However, these …

The pHLIP peptide has three states: (I) soluble in aqueous buffer, (II) bound to the bilayer
surface at neutral pH, and (III) inserted as a transmembrane (TM) helix at acidic pH. The …

Several diseases, such as cancer, are characterized by acidification of the extracellular
environment. Acidosis can be employed as a target to specifically direct therapies to the …

The α splice variant of p73 (p73α), a homologue of the tumor suppressor p53, has close to
its C terminus a sterile α motif (SAM), SAMp73, that is thought to be involved in protein-protein …

pHLIPs are a family of soluble ∼36 amino acid peptides, which bind to membrane surfaces.
If the environment is acidic, a pHLIP folds and inserts across the membrane to form a stable …

We have used pHLIP® [pH (low) insertion peptide] to study the roles of carboxyl groups in
transmembrane (TM) peptide insertion. pHLIP binds to the surface of a lipid bilayer as a …

Single-pass membrane receptors contain extracellular domains that respond to external stimuli
and transmit information to intracellular domains through a single transmembrane (TM) α-…