[PDF][PDF] Hoxa2 selectively enhances Meis binding to change a branchial arch ground state
Hox transcription factors (TFs) are essential for vertebrate development, but how these
evolutionary conserved proteins function in vivo remains unclear. Because Hox proteins have …
evolutionary conserved proteins function in vivo remains unclear. Because Hox proteins have …
Hox regulation of transcription: more complex (es)
F Ladam, CG Sagerström - Developmental Dynamics, 2014 - Wiley Online Library
Hox genes encode transcription factors with important roles during embryogenesis and tissue
differentiation. Genetic analyses initially demonstrated that interfering with Hox genes has …
differentiation. Genetic analyses initially demonstrated that interfering with Hox genes has …
[HTML][HTML] ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis
M Dumortier, F Ladam, I Damour, S Vacher… - Breast Cancer …, 2018 - Springer
Background The ETS transcription factor ETV4 is involved in the main steps of organogenesis
and is also a significant mediator of tumorigenesis and metastasis, such as in breast …
and is also a significant mediator of tumorigenesis and metastasis, such as in breast …
[PDF][PDF] TALE factors poise promoters for activation by Hox proteins
SK Choe, F Ladam, CG Sagerström - Developmental cell, 2014 - cell.com
Hox proteins form complexes with TALE cofactors from the Pbx and Prep/Meis families to
control transcription, but it remains unclear how Hox:TALE complexes function. Examining a …
control transcription, but it remains unclear how Hox:TALE complexes function. Examining a …
Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3-or Erm-dependent transcription
V Firlej, F Ladam, G Brysbaert, P Dumont… - Journal of cell …, 2008 - journals.biologists.com
Pea3 and Erm are transcription factors expressed in normal developing branching organs
such as the mammary gland. Deregulation of their expression is generally associated with …
such as the mammary gland. Deregulation of their expression is generally associated with …
TALE factors use two distinct functional modes to control an essential zebrafish gene expression program
F Ladam, W Stanney, IJ Donaldson, O Yildiz, N Bobola… - Elife, 2018 - elifesciences.org
10.7554/eLife.36144.001 TALE factors are broadly expressed embryonically and known to
function in complexes with transcription factors (TFs) like Hox proteins at gastrula/…
function in complexes with transcription factors (TFs) like Hox proteins at gastrula/…
A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree
M Losa, V Latorre, M Andrabi, F Ladam, C Sagerström… - Elife, 2017 - elifesciences.org
10.7554/eLife.31362.001 Connection of the heart to the systemic circulation is a critical
developmental event that requires selective preservation of embryonic vessels (aortic arches). …
developmental event that requires selective preservation of embryonic vessels (aortic arches). …
[HTML][HTML] Combinatorial action of NF–Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish
W Stanney III, F Ladam, IJ Donaldson, TJ Parsons… - Developmental …, 2020 - Elsevier
Animal embryogenesis is initiated by maternal factors, but zygotic genome activation (ZGA)
shifts regulatory control to the embryo during blastula stages. ZGA is thought to be mediated …
shifts regulatory control to the embryo during blastula stages. ZGA is thought to be mediated …
Loss of a negative feedback loop involving pea3 and cyclin d2 is required for pea3-induced migration in transformed mammary epithelial cells
F Ladam, I Damour, P Dumont, Z Kherrouche… - Molecular Cancer …, 2013 - AACR
The Ets family transcription factor Pea3 (ETV4) is involved in tumorigenesis especially
during the metastatic process. Pea3 is known to induce migration and invasion in mammary …
during the metastatic process. Pea3 is known to induce migration and invasion in mammary …
A Gal4/UAS system for conditional transgene expression in rhombomere 4 of the zebrafish hindbrain
SK Choe, M Nakamura, F Ladam… - Developmental …, 2012 - Wiley Online Library
Background: The zebrafish is well established as a model organism for the study of vertebrate
embryogenesis, but transgenic lines enabling restricted gene expression are still lacking …
embryogenesis, but transgenic lines enabling restricted gene expression are still lacking …