Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle beyond the
inherent regenerative capacity of the body, generally leading to severe functional deficit. …

Functional restoration following major peripheral nerve injury (PNI) is challenging, given slow
axon growth rates and eventual regenerative pathway degradation in the absence of axons…

Strategies to accelerate the rate of axon regeneration would improve functional recovery
following peripheral nerve injury, in particular for cases involving segmental nerve defects. We …

BACKGROUND Millions of Americans experience residual deficits from traumatic peripheral
nerve injury (PNI). Despite advancements in surgical technique, repair typically results in …

… Laimo… Brown, and Franco A. Laimo, performed histological assessment and confocal
imaging, and figure preparation. Justin C. Burrell and Dan P. …

Nerve injury requiring surgical repair often results in poor functional recovery due to the
inability of host axons to re-grow long distances and reform meaningful connections with the …

Facial nerve trauma often leads to disfiguring facial muscle paralysis. Despite several promising
advancements, facial nerve repair procedures often do not lead to complete functional …

Peripheral nerve injury (PNI) impacts millions annually, often leaving debilitated patients with
minimal repair options to improve functional recovery. Our group has previously developed …

Existing strategies for repair of major peripheral nerve injury (PNI) are inefficient at promoting
axon regeneration and functional recovery and are generally ineffective for nerve lesions >…

Tissue engineered nerve grafts (TENGs) built from living neurons and aligned axon tracts
offer a revolutionary new approach as “living scaffolds” to bridge major peripheral nerve …