Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

Chromosome conformation capture methods have identified subchromosomal structures of
higher-order chromatin interactions called topologically associated domains (TADs) that are …

Genomic structural variants have long been implicated in phenotypic diversity and human
disease, but dissecting the mechanisms by which they exert their functional impact has proven …

Cleft lip with or without cleft palate (CL/P) is one of the most common congenital malformations
observed in humans, with 1 occurrence in every 500–1,000 births 1 , 2 . A 640-kb …

More than forty per cent of the mammalian genome is derived from retroelements, of which
about one-quarter are endogenous retroviruses (ERVs) 1 . Some are still active, notably in …

During limb development, coordinated expression of several Hoxd genes is required in
presumptive digits. We searched for the underlying control sequences upstream from the cluster …

The emergence and diversification of cell types is a leading factor in animal evolution. So far,
systematic characterization of the gene regulatory programs associated with cell type …

Gene expression often requires interaction between promoters and distant enhancers,
which occur within the context of highly organized topologically associating domains (TADs). …

The evolution of digits was an essential step in the success of tetrapods. Among the key
players, Hoxd genes are coordinately regulated in developing digits, where they help organize …