Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

End‐stage liver diseases are an increasing health burden, and liver transplantations are
currently the only curative treatment option. Due to a lack of donor livers, alternative treatments …

Background and Aims The gap between patients on transplant waiting lists and available
donor organs is steadily increasing. Human organoids derived from leucine‐rich repeat‐…

The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases
caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. …

The shortage of liver organ donors is increasing and the need for viable alternatives is urgent.
Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with …

Background Inbreeding and population bottlenecks in the ancestry of Friesian horses has led
to health issues such as dwarfism. The limbs of dwarfs are short and the ribs are protruding …

Background Hydrocephalus in Friesian horses is a developmental disorder that often results
in stillbirth of affected foals and dystocia in dams. The occurrence is probably related to a …

Recent technical advances in the stem cell field have enabled the in vitro generation of
complex structures resembling whole organs termed organoids. Most of these approaches …

Copper toxicosis is a complex genetic disorder in Labrador retrievers characterized by hepatic
copper accumulation eventually leading to liver cirrhosis. The variation of hepatic copper …

Background An inherited basis for congenital extrahepatic portosystemic shunts (EHPSS)
has been demonstrated in several small dog breeds. If in general both portocaval and porto-…