Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Smoking is a leading cause of preventable death, causing about 5 million premature deaths
worldwide each year 1 , 2 . Evidence for genetic influence on smoking behaviour and …

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …

The common sequence variants that have recently been associated with cancer risk are
particular to a single cancer type or at most two. Following up on our genome-wide scan of …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

Familial clustering studies indicate that breast cancer risk has a substantial genetic
component 1 , 2 , 3 . To identify new breast cancer risk variants, we genotyped approximately …

Smoking is a common risk factor for many diseases 1 . We conducted genome-wide
association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = …

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …