Glycogen synthase kinase 3 (GSK3) is a key regulator in signaling pathways in both animals
and plants. Three Arabidopsis thaliana GSK3s are shown to be related to brassinosteroid (…

The adipocyte-derived hormone leptin signals the status of body energy stores by activating
its receptor in hypothalamic nuclei. In contrast to the initial expectations, leptin treatment of …

Peripheral lipoprotein lipase (LPL)-mediated lipolysis of triglycerides is the first step in
chylomicron/VLDL clearance involving heparan sulfate proteoglycans (HSPGs) displayed at the …

The suppressors of cytokine signalling (SOCS) box is a structural domain found at the C-terminus
of over 70 human proteins. It is usually coupled to a protein interaction module such as …

The leptin/leptin receptor system shows strong similarities to the long-chain cytokine
interleukin-6 (IL-6) and granulocyte colony-stimulating factor cytokine/receptor systems. The IL-6 …

The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the
pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, …

Leptin was originally discovered as an adipocyte-derived hormone involved in the central
control of body weight and energy homeostasis. It is now clear that leptin is a pleiotropic …

Purpose We aimed to identify the genetic cause in a cohort of 11 unrelated cases and two
sisters with 46,XX SRY-negative (ovo)testicular disorders of sex development (DSD). Methods …

Broadly neutralizing antibodies are an important treatment for individuals with coronavirus
disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS…

An alignment of the mammalian ABCA transporters enabled the identification of sequence
segments, specific to the ABCA subfamily, which were used as queries to search for …