While mammals have a limited capacity to repair bone defects, zebrafish can completely
regenerate amputated bony structures of their fins. Fin regeneration is dependent on formation …

Zebrafish have an unlimited capacity to regenerate bone after fin amputation. In this process,
mature osteoblasts dedifferentiate to osteogenic precursor cells and thus represent an …

The transition from fins to limbs was an important terrestrial adaptation, but how this crucial
evolutionary shift arose developmentally is unknown. Current models focus on the distinct …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited. Indeed…

Systems for spatial and temporal control of gene expression are essential for developmental
studies and are of particular importance for research in adult model organisms. We present …

Glucocorticoids are widely used as therapeutic agents to treat immune‐mediated diseases
in humans because of their anti‐inflammatory and immunosuppressive effects. However, …

Natural killer (NK) cells are attractive effectors for adoptive immunotherapy of cancer. Results
from first-in-human studies using chimeric antigen receptor (CAR)-engineered primary NK …

Long-term glucocorticoid administration in patients undergoing immunosuppressive and anti-inflammatory
treatment is accompanied by impaired bone formation and increased fracture …

Rationale: Current therapies for metastatic osseous disease frequently fail to provide a
durable treatment response. To date, there are only limited therapeutic options for metastatic …

Cancer stem cells (CSC) are characterized by high self-renewal capacity, tumor-initiating
potential, and therapy resistance. Aldehyde dehydrogenase (ALDH)+ cell population serves as …