Background Accumulation of extracellular matrix in organs and tissues is a feature of both
aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis accompany …

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the
oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate …

Talin, vinculin, and paxillin are core components of the dynamic link between integrins and
actomyosin. Here, we study the mechanisms that mediate their activation and association …

Cell-matrix interactions and podocyte intercellular junctions are key for maintaining the
glomerular filtration barrier. Vinculin, a cytoplasmic protein, couples actin filaments to integrin-…

Cells have evolved mechanisms to sense the composition of their adhesive microenvironment.
Although much is known about general mechanisms employed by adhesion receptors to …

Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on
kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of …

Low-intensity pulsed ultrasound (LIPUS) is a therapy used clinically to promote healing.
Using live-cell imaging we show that LIPUS stimulation, acting through integrin-mediated cell-…

Background The kidney contains distinct glomerular and tubulointerstitial compartments
with diverse cell types and extracellular matrix components. The role of immune cells in …

Talin, vinculin and paxillin are core components of the dynamic link between integrins and
actomyosin. Here we study the mechanisms that mediate their activation and association …

The 13th International Podocyte Conference was held in Manchester, UK, and online from
July 28 to 30, 2021. Originally planned for 2020, this biannual meeting was postponed by a …