▪ Abstract SUMO (small ubiquitin-related modifier) is the best-characterized member of a
growing family of ubiquitin-related proteins. It resembles ubiquitin in its structure, its ability to be …

A protein called small ubiquitin-related modifier (SUMO) can be coupled to other proteins to
control their function. This SUMOylation has been implicated in the regulation of a host of …

We have found that the mammalian Ran GTPase–activating protein RanGAP1 is highly
concentrated at the cytoplasmic periphery of the nuclear pore complex (NPC), where it …

Nuclear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange. To analyze
their structure in a close-to-life state, we studied transport-active, intact nuclei from …

A decade has passed since SUMO (small ubiquitin-related modifier) was discovered to be a
reversible post-translational protein modifier. During this time many enzymes that participate …

Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of …

Posttranslational modification with SUMO1 regulates protein/protein interactions, localization,
and stability. SUMOylation requires the E1 enzyme Aos1/Uba2 and the E2 enzyme Ubc9. …

Post-translational modifiers of the SUMO (S mall U biquitin-related M odifier) family have
emerged as key regulators of protein function and fate. While the past few years have seen an …

The Wnt-responsive transcription factor LEF1 can activate transcription in association with β-catenin
and repress transcription in association with Groucho. In search of additional …

The recently discovered small ubiquitin-related modifier SUMO-1 belongs to the growing
family of ubiquitin-related proteins involved in postranslational protein modification. Unlike …