The proteolytic cleavages elicited by activation of the Notch receptor release an intracellular
fragment, Notch intracellular domain, which enters the nucleus to activate the transcription …

Notch is the receptor in one of a small group of conserved signaling pathways that are
essential at multiple stages in development. Although the mechanism of transduction impinges …

Gait disorders and postural instability, which are commonly observed in elderly patients with
Parkinson disease (PD), respond poorly to dopaminergic agents used to treat other …

Objective Repair of demyelinated axons in diseases such as multiple sclerosis requires
activation of the myelination program in existing or newly recruited oligodendrocyte precursor …

Numerous functional imaging studies have shown that retrieval from semantic and episodic
memory is subserved by distinct neural networks. However, these results were essentially …

Autism involves impairments in communication and social interaction, as well as high levels
of repetitive, stereotypic, and ritualistic behaviours, and extreme resistance to change. This …

The diverse functions of Notch signalling imply that it must elicit context-specific programmes
of gene expression. With the aim of investigating how Notch drives cells to differentiate, we …

After outlining the general characteristics of high-energy ball-milling, mechanochemical
synthesis is argued to be an attractive method for the synthesis and transformation of materials. …

Anaplastic lymphoma kinase (ALK)-positive lymphomas are characterized by expression of
a hybrid protein, comprising the cytoplasmic portion of the ALK tyrosine kinase fused to a …

Although communication and social difficulties in autism have received a great deal of
research attention, the other key diagnostic feature, extreme repetitive behaviour and unusual …