Amyotrophic Lateral Sclerosis (ALS) is being redefined as a distal axonopathy, in that many
molecular changes influencing motor neuron degeneration occur at the neuromuscular …

Semaphorins, originally discovered as guidance cues for developing axons, are involved in
many processes that shape the nervous system during development, from neuronal …

Injury to the mature mammalian central nervous system (CNS) is often accompanied by
permanent loss of function of the damaged neural circuits. The failure of injured CNS axons to …

Neuromuscular synapses differ markedly in their plasticity. Motor nerve terminals innervating
slow muscle fibers sprout vigorously following synaptic blockage, while those innervating …

Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical role …

… Moloney a , Gera Neufeld d , Fred de Winter a f , James W. Fawcett b , Joost Verhaagen a
e … 2D) were similar to those observed with antibodies C17 and N15. This Sema3B antibody …

INTRODUCTION Motivational drives are internal states that can be different even in similar
interactions with external stimuli. Curiosity as the motivational drive for novelty-seeking and …

The correct subcellular distribution of proteins establishes the complex morphology and
function of neurons. Fluorescence microscopy techniques are invaluable to investigate …

Secreted semaphorins are essential for neural development and continue to be expressed
in subpopulations of adult neurons, where they subserve as yet unknown functions. We …

Aging is associated with increased prevalence of axonal injuries characterized by poor
regeneration and disability. However, the underlying mechanisms remain unclear. In our …