User profiles for Frederic Gachon
 | Frédéric GachonThe University of Queensland Verified email at uq.edu.au Cited by 6794 |
The mammalian circadian timing system: from gene expression to physiology
Many physiological processes in organisms from bacteria to man are rhythmic, and some of
these are controlled by self-sustained oscillators that persist in the absence of external time …
these are controlled by self-sustained oscillators that persist in the absence of external time …
Chronopharmacology: new insights and therapeutic implications
Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …
[PDF][PDF] Medicine in the fourth dimension
The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …
even more when translating to the bedside. Circadian biology is becoming a critical factor for …
[HTML][HTML] The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification
F Gachon, FF Olela, O Schaad, P Descombes… - Cell metabolism, 2006 - cell.com
The PAR-domain basic leucine zipper (PAR bZip) transcription factors DBP, TEF, and HLF
accumulate in a highly circadian manner in several peripheral tissues, including liver and …
accumulate in a highly circadian manner in several peripheral tissues, including liver and …
Circadian clock-dependent and-independent rhythmic proteomes implement distinct diurnal functions in mouse liver
…, P Waridel, M Quadroni, F Gachon… - Proceedings of the …, 2014 - National Acad Sciences
Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic
physiology across most living organisms. Although such rhythms have been extensively …
physiology across most living organisms. Although such rhythms have been extensively …
The loss of circadian PAR bZip transcription factors results in epilepsy
DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph
embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich …
embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich …
The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription
G Gaudray, F Gachon, J Basbous… - Journal of …, 2002 - Am Soc Microbiol
The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins
involved in infectivity, replication, and transformation. We report in this study the …
involved in infectivity, replication, and transformation. We report in this study the …
Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver
Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most
living organisms. Such oscillations are controlled by the interplay between the circadian clock …
living organisms. Such oscillations are controlled by the interplay between the circadian clock …
Guidelines for genome-scale analysis of biological rhythms
Genome biology approaches have made enormous contributions to our understanding of
biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and …
biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and …
[PDF][PDF] The mouse microbiome is required for sex-specific diurnal rhythms of gene expression and metabolism
The circadian clock and associated feeding rhythms have a profound impact on metabolism
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …