Drosophila Suppressor of fused (Su(fu)) encodes a novel 468-amino-acid cytoplasmic protein
which, by genetic analysis, functions as a negative regulator of the Hedgehog segment …

Basal-cell carcinomas (BCCs) are the commonest human cancer 1 . Insight into their genesis
came from identification of mutations in the PATCHED gene (PTCH) in patients with the …

The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers,
including medulloblastoma, an aggressive brain tumor. GDC-0449, a drug that inhibits Hh …

Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells.
Despite increasing evidence that high levels of IL-17 are associated with several chronic …

Background Mutations in hedgehog pathway genes, primarily genes encoding patched
homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a …

Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and
thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic …

<p id="p001">Medulloblastoma is the most common malignant brain tumor in children. Aberrant
activation of the hedgehog signaling pathway is strongly implicated in the development …

The systematic characterization of somatic mutations in cancer genomes is essential for
understanding the disease and for developing targeted therapeutics 1 . Here we report the …

Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis.
Here, we obtained exome, transcriptome and copy-number alteration data from …

Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated
with tumorigenesis in a number of human tissues 1 , 2 , 3 , 4 , 5 , 6 , 7 . Here we show that, …