Purpose: MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and
extraterminal (BET) bromodomain inhibition has recently been shown to suppress MYC-…

Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant
neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor …

The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To
clarify how developmental and regional differences influence transformation, we transduced …

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Sonic
Hedgehog (SHH) signaling drives a minority of MB, correlating with desmoplastic pathology and …

We undertook a comprehensive clinical and biological investigation of serial medulloblastoma
biopsies obtained at diagnosis and relapse. Combined MYC family amplifications and …

Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Background Glioblastoma (GBM) is refractory to immune checkpoint inhibitor (ICI) therapy.
We sought to determine to what extent this immune evasion is due to intrinsic properties of the …

Medulloblastoma (MB) is the most common malignant brain tumor in children. MYC genes
are frequently amplified and correlate with poor prognosis in MB. BET bromodomains …

Earlier we used a glioma model to identify loci in the mouse genome, which were repeatedly
targeted by platelet-derived growth factor (PDGF)-containing Moloney murine leukemia …

Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease
presents with a complex spectrum of genomic aberrations, but the pharmacological …