Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol.
Tetramer destabilization and misfolding of the released monomers result in TTR aggregation, …

Glycoproteomics has rapidly become an independent analytical platform bridging the fields
of glycomics and proteomics to address site-specific protein glycosylation and its impact in …

Vertebrates produce various chondroitin sulfate proteoglycans (CSPGs) that are important
structural components of cartilage and other connective tissues. CSPGs also contribute to the …

Proteoglycans (PGs), a class of carbohydrate-modified proteins, are present in essentially
all metazoan organisms investigated to date. PGs are composed of glycosaminoglycan (GAG) …

Background: Serum amyloid A (SAA) is normally associated with the high-density lipoprotein
(HDL). Results: Heparan sulfate (HS) dissociates SAA from HDL, leading to AA amyloidosis…

Heparan sulfate (HS) and chondroitin sulfate (CS) are complex polysaccharides that regulate
important biological pathways in virtually all metazoan organisms. The polysaccharides …

Synapses are the minimal information processing units of the brain and come in many flavors
across distinct circuits. The shape and properties of a synapse depend on its molecular …

Chondroitin sulfate proteoglycans (CSPGs) are found at cell surfaces and in connective
tissues, where they interact with a multitude of proteins involved in various pathophysiological …

Chondroitin sulfate proteoglycans (CSPGs) are important structural components of connective
tissues in essentially all metazoan organisms. In vertebrates, CSPGs are involved also in …

Sulfs represent a class of unconventional sulfatases which provide an original post-synthetic
regulatory mechanism for heparan sulfate polysaccharides and are involved in multiple …